Gamitrinib TPP hexafluorophosphate |CAS:1131626-47-5 Probechem Biochemicals

Chemical Structure : Gamitrinib TPP hexafluorophosphate

CAS No.: 1131626-47-5

Gamitrinib TPP hexafluorophosphate

Catalog No.: PC-38121Not For Human Use, Lab Use Only.

Gamitrinib is a small molecule mitochondrial Hsp90 inhibitor, selectively targets Hsp90 network in tumor mitochondria.

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1 mg	$268	In stock
5 mg	$758	In stock
10 mg	$1280	In stock
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Biological Activity

Gamitrinib is a small molecule mitochondrial Hsp90 inhibitor, selectively targets Hsp90 network in tumor mitochondria.
Gamitrinibs were shown to accumulate in the mitochondria of human tumor cell lines and to inhibit Hsp90 activity by acting as ATPase antagonists.
Unlike Hsp90 antagonists not targeted to mitochondria, Gamitrinibs exhibited a "mitochondriotoxic" mechanism of action, causing rapid tumor cell death and inhibiting the growth of xenografted human tumor cell lines in mice.
Gamitrinib is not toxic to normal cells or tissues and did not affect Hsp90 homeostasis in cellular compartments other than mitochondria.

Physicochemical Properties

M.Wt	1036.04
Formula	C52H65F6N3O8P2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6-(((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-(carbamoyloxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-19-yl)amino)hexyl)triphenylphosphonium hexafluorophosphate(V)

References

1. Wei S, et al. Clin Cancer Res. 2022 Mar 4:clincanres.0833.2021.

2. Kang BH, et al. J Clin Invest. 2009 Mar;119(3):454-64.

3. Kang BH, et al. Br J Cancer. 2011 Feb 15;104(4):629-34.

4. Park HK, et al. Mol Cancer. 2014 Jun 12;13:148.