Catalog No.: PC-61378Not For Human Use, Lab Use Only.
Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
Ganaplacide (KAF156, GNF-156) is a novel antimalarial clinical candidate that shows blood schizonticidal activity with IC50 of 6-17.4 nM against P falciparum drug-sensitive and drug-resistant strains.
KAF156 demonstrates potent therapeutic activity in mouse models of malaria with 50, 90, and 99% effective doses of 0.6, 0.9, and 1.4 mg/kg, respectively.
KAF156 is completely protective as a single oral dose of 10 mg/kg in sporozoite challenge mouse model.
KAF156 shows the potential to treat, prevent, and block the transmission of malaria.
