Gedunin |CAS:2753-30-2 Probechem Biochemicals

Chemical Structure : Gedunin

CAS No.: 2753-30-2

Gedunin

Catalog No.: PC-60607Not For Human Use, Lab Use Only.

Gedunin is a natural tetranortriterpenoid compound that inhibits Hsp90 and induce the degradation of Hsp90-dependent client proteins.

Packing	Price	Stock
1 mg	$328	In stock
5 mg	$758	In stock
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Biological Activity

Gedunin is a natural tetranortriterpenoid compound that inhibits Hsp90 and induce the degradation of Hsp90-dependent client proteins.
Gedunin displays antiproliferative activity in vitro with IC50 of 3.22, 8.84 and 16.8 uM in SKBr3, MCF-7 and CaCo-2 cancer cell lines respectively.
Gedunin also shows potential antimalarial activity against P. falciparum.

Physicochemical Properties

M.Wt	482.57
Formula	C28H34O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	100 mM in DMSO
Chemical Name/SMILES	(1S,3aS,4aR,4bS,5R,6aR,10aR,10bR,12aS)-5-(Acetyloxy)-1-(3-furanyl)-1,5,6,6a,7,10a,10b,11,12,12a,decahydro-4b,7,7,10a,12a,-pentamethyloxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione

References

1. MacKinnon S, et al. J Nat Prod. 1997 Apr;60(4):336-41.

2. Brandt GE, et al. J Med Chem. 2008 Oct 23;51(20):6495-502.

3. Kamath SG, et al. Int J Gynecol Cancer. 2009 Dec;19(9):1564-9.

4. Olesen SH, et al. Molecules. 2015 Jan 19;20(1):1643-60.

Gedunin

Biological Activity

Physicochemical Properties

References

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