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Chemical Structure : Gefapixant
CAS No.: 1015787-98-0
Catalog No.: PC-61379Not For Human Use, Lab Use Only.
Gefapixant (AF-219, MK-7264) is an orally active, small molecule antagonist of P2X3-containing receptor with IC50 of 30 nM (hP2X3 homotrimer) and 100-250 nM (hP2X2/3 heterotrimer).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $458 | In stock | |
| 250 mg | Get quote |
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Gefapixant (AF-219, MK-7264) is an orally active, small molecule antagonist of P2X3-containing receptor with IC50 of 30 nM (hP2X3 homotrimer) and 100-250 nM (hP2X2/3 heterotrimer).
Gefapixant (AF-219, MK-7264) displays no inhibitory impact on any non-P2X3 subunit containing receptors (IC50 >10,000 nM at recombinant homotrimeric hP2X1, hP2X2, hP2X4, rP2X5 and hP2X7 channels).
Gefapixant (AF-219, MK-7264) markedly and significantly reduced objective cough frequency in clinical trials.
| M.Wt | 353.397 | |
| Formula | C14H19N5O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-[(2,4-diaminopyrimidin-5-yl)oxy]-2-methoxy-4-(propan-2-yl)benzene-1-sulfonamide |
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1. Abdulqawi R, et al. Lancet. 2015 Mar 28;385(9974):1198-205.
2. Ford AP, et al. Front Cell Neurosci. 2013 Dec 19;7:267.
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