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Geldanamycin

Chemical Structure : Geldanamycin

CAS No.: 30562-34-6

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Geldanamycin

Catalog No.: PC-23154Not For Human Use, Lab Use Only.

Geldanamycin is a small molecule Hsp90 inhibitor, binds to HSP90 and destabilizes its association with other proteins, shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Geldanamycin is a small molecule Hsp90 inhibitor, binds to HSP90 and destabilizes its association with other proteins, shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.

Physicochemical Properties

M.Wt 560.64
Formula C29H40N2O9
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

References

1. Kitson RRA, et al. J Med Chem. 2024 Oct 3. doi: 10.1021/acs.jmedchem.4c01048.

2. Schulte TW, et al. Mol Cell Biol. 1996 Oct;16(10):5839-45.

3. Smith DF, et al. Mol Cell Biol. 1995 Dec;15(12):6804-12.

4. Whitesell L, et al. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8324-8.

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