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Chemical Structure : Gemigliptin
CAS No.: 911637-19-9
Catalog No.: PC-60974Not For Human Use, Lab Use Only.
Gemigliptin (LC15-0444) is a potent, selective, competitive and orally active DPP4 inhibitor (IC50=10.4 nM, hDPP4) with potential for the treatment of type 2 diabetes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Gemigliptin (LC15-0444) is a potent, selective, competitive and orally active DPP4 inhibitor (IC50=10.4 nM, hDPP4) with potential for the treatment of type 2 diabetes.
Gemigliptin exhibits potent anti-glycation properties in vitro and in vivo, also improves renal function and attenuates podocyte injury in mice with diabetic nephropathy.
| M.Wt | 489.37 | |
| Formula | C18H19F8N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one |
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1. Lim KS, et al. Br J Clin Pharmacol. 2009 Dec;68(6):883-90.
2. Hwang HJ, et al. Mol Cell Endocrinol. 2014 Jul 5;392(1-2):1-7.
3. Jung E, et al. Eur J Pharmacol. 2014 Dec 5;744:98-102.
4. Jung E, et al. Eur J Pharmacol. 2015 Aug 15;761:116-24.
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