Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.

You are here:Home-Chemical Inhibitors & Agonists-Metabolic Enzyme/Protease-Dipeptidyl Peptidase (DPP)-Gemigliptin
Gemigliptin

Chemical Structure : Gemigliptin

CAS No.: 911637-19-9

Gemigliptin (LC15-0444;LC150444;LC 150444)

Catalog No.: PC-60974Not For Human Use, Lab Use Only.

Gemigliptin (LC15-0444) is a potent, selective, competitive and orally active DPP4 inhibitor (IC50=10.4 nM, hDPP4) with potential for the treatment of type 2 diabetes.

Packing Price Stock Quantity
10 mg $128 In stock
25 mg $198 In stock
50 mg $328 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Gemigliptin (LC15-0444) is a potent, selective, competitive and orally active DPP4 inhibitor (IC50=10.4 nM, hDPP4) with potential for the treatment of type 2 diabetes.
Gemigliptin exhibits potent anti-glycation properties in vitro and in vivo, also improves renal function and attenuates podocyte injury in mice with diabetic nephropathy.

Physicochemical Properties

M.Wt 489.37
Formula C18H19F8N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-1-(2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)-4-oxobutyl)-5,5-difluoropiperidin-2-one

References

1. Lim KS, et al. Br J Clin Pharmacol. 2009 Dec;68(6):883-90.

2. Hwang HJ, et al. Mol Cell Endocrinol. 2014 Jul 5;392(1-2):1-7.

3. Jung E, et al. Eur J Pharmacol. 2014 Dec 5;744:98-102.

4. Jung E, et al. Eur J Pharmacol. 2015 Aug 15;761:116-24.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: