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Genz-667348

Chemical Structure : Genz-667348

CAS No.: 1195774-46-9

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Genz-667348 (Genz 667348)

Catalog No.: PC-20266Not For Human Use, Lab Use Only.

Genz-667348 (Genz667348) is a potent, selective P. falciparum DHODH inhibitor with IC50 of 22, 14 and 42 nM for PfDHODH, PbDHODH and PvDHODH, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Genz-667348 (Genz667348) is a potent, selective P. falciparum DHODH inhibitor with IC50 of 22, 14 and 42 nM for PfDHODH, PbDHODH and PvDHODH, respectively.
    Genz-667348 demonstrates in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC50 of 7 and 10 nM, respectively.
    Genz-667348 (ED50=21.0 mg/kg/day) demonstrates in vivo efficacy in the P. berghei mouse model.

    Physicochemical Properties

    M.Wt 381.37
    Formula C17H14F3N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-cyclopropyl-5-(2-methyl-5-(trifluoromethoxy)-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide

    References

    1. Michael L Booker, et al. J Biol Chem. 2010 Oct 22;285(43):33054-33064.

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