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Gingerenone A

Chemical Structure : Gingerenone A

CAS No.: 128700-97-0

Gingerenone A (Dual JAK2/S6K1 inhibitor)

Catalog No.: PC-60874Not For Human Use, Lab Use Only.

Gingerenone A is a dual inhibitor of JAK2 and S6K1 pathways, selectively kills cancer cells while exhibiting minimal toxicity toward normal cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Gingerenone A is a dual inhibitor of JAK2 and S6K1 pathways, selectively kills cancer cells while exhibiting minimal toxicity toward normal cells.
Gingerenone A induces apoptosis in cancer cells and suppresses tumor growth in vivo associated with relative phosphorylation levels of JAK2 and S6K1.
Gingerenone A suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice.

Physicochemical Properties

M.Wt 356.418
Formula C21H24O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Hepten-3-one, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E)-

References

1. Byun S, et al. J Biol Chem. 2015 Sep 25;290(39):23553-62.

2. Kim HJ, et al. J Cell Biochem. 2018 Jan;119(1):260-268.

3. Suk S, et al. Mol Nutr Food Res. 2017 Oct;61(10).

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