Catalog No.: PC-21193Not For Human Use, Lab Use Only.
Gliotoxin (Aspergillin) is a virulence factor of Aspergillus fumigatus, functions as a potent and selective inhibitor of the epoxide hydrolase activity of LTA4 hydrolase (LTA4H), selectively inhibits LTB4 biosynthesis.
Gliotoxin (Aspergillin) is a virulence factor of Aspergillus fumigatus, functions as a potent and selective inhibitor of the epoxide hydrolase activity of LTA4 hydrolase (LTA4H), selectively inhibits LTB4 biosynthesis. Gliotoxin selectively suppresses LTB4 biosynthesis and blocks neutrophil recruitment in vivo. Gliotoxin potently and selectively inhibits LTB4 biosynthesis in human neutrophils and monocytes (IC50=0.8 uM). Gliotoxin efficiently reduces LTB4 formation but failed to inhibit the aminopeptidase activity up to 10 μM in human neutrophils. Gliotoxin causes specific suppression of LTB4 biosynthesis without inhibiting the formation of additional products from the same substrate (i.e., LTA4) or related LMs generated by other enzymatic eicosanoid pathways.
