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Glutamate-cysteine ligase inhibitor EN25

Chemical Structure : Glutamate-cysteine ligase inhibitor EN25

CAS No.: 1647534-29-9

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Glutamate-cysteine ligase inhibitor EN25 (GCL inhibitor EN25)

Catalog No.: PC-21231Not For Human Use, Lab Use Only.

Glutamate-cysteine ligase inhibitor EN25 is a covalent inhibitor of the glutamate-cysteine ligase (GCL) with IC50 of 16 uM, targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Glutamate-cysteine ligase inhibitor EN25 is a covalent inhibitor of the glutamate-cysteine ligase (GCL) with IC50 of 16 uM, targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL.
Glutamate-cysteine ligase inhibitor EN25 inhibits GCL activity, lowers cellular GSH levels, and impairs cell viability in ARID1A-deficient cancer cells that are particularly vulnerable to glutathione depletion, but not in ARID1A-positive cancer cells.

Physicochemical Properties

M.Wt 416.54
Formula C25H24N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(acrylamidomethyl)-N-(4-((3,4-dimethylphenyl)thio)phenyl)benzamide

References

1. Lydia Zhang, et al. Chembiochem. 2023 Sep 27;e202300371.

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