GlyphAllo | GABAA PAM | Probechem Biochemicals

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Chemical Structure : GlyphAllo

GlyphAllo (SPT-300, SPT300, Glyph Allopregnanolone)

Catalog No.: PC-28340Not For Human Use, Lab Use Only.

GlyphAllo (SPT-300, Glyph Allopregnanolone) is an oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport, shows neuroactive steroid antidepressant and anxiolytic activity via GABAA (γ-aminobutyric acid type A) receptor positive allosteric modulation.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	847.14
Formula	C48H78O12
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-((((((3R,5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)carbonyl)oxy)methyl) 5-(1,3-bis(octanoyloxy)propan-2-yl) 3-methylpentanedioate

References

1. Simpson JS, et al. Sci Transl Med. 2026 Mar 25;18(842):eadu2352.

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GlyphAllo (SPT-300, SPT300, Glyph Allopregnanolone)

Biological Activity

Physicochemical Properties

References

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