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Golgicide A

Chemical Structure : Golgicide A

CAS No.: 1139889-93-2

Golgicide A

Catalog No.: PC-62234Not For Human Use, Lab Use Only.

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM.

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Biological Activity

Golgicide A is a potent, highly specific, reversible inhibitor of the cis-Golgi ArfGEF GBF1, inhibits the effect of shiga toxin on protein synthesis with IC50 of 3.3 uM.
Golgicide A causes complete dispersal of the medial-Golgi markers giantin and the cis-Golgi marker GM130
Golgicide A causes a decrease in GBF1-mediated Arf1 activation; inhibits swine vesicular disease virus (SVDV) procution.

Physicochemical Properties

M.Wt 284.31
Formula C17H14F2N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3aR,9bS)-6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

References

1. Sáenz JB, et al. Nat Chem Biol. 2009 Mar;5(3):157-65.

2. Ignashkova TI, et al. Traffic. 2017 Aug;18(8):530-544.

3. Vázquez-Calvo Á, et al. Front Microbiol. 2016 Apr 27;7:612.

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