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Gosogliptin

Chemical Structure : Gosogliptin

CAS No.: 869490-23-3

Gosogliptin (PF-00734200, PF-734200, PF734200, PF00734200)

Catalog No.: PC-60516Not For Human Use, Lab Use Only.

Gosogliptin (PF-734200, PF-00734200) is a potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Gosogliptin (PF-734200, PF-00734200) is a potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.
Gosogliptin demonstrates >200-fold selectivity over other members of the DPP family (DPP-2, DPP-3, DPP-8, and DPP-9) and the related serine proteases, FAP, aminopeptidase P, and propyl oligopeptidase.
Gosogliptin shows potential treatment for type 2 diabetes.

Physicochemical Properties

M.Wt 366.417
Formula C17H24F2N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone

References

1. Ammirati MJ, et al. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1991-5.

2. Dai H, et al. Br J Clin Pharmacol. 2011 Jul;72(1):85-91.

3. Sharma R, et al. Drug Metab Dispos. 2012 Nov;40(11):2143-61.

4. Rosenstock J, et al. Diabet Med. 2011 Apr;28(4):464-9.

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