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Chemical Structure : Gosogliptin
Catalog No.: PC-60516Not For Human Use, Lab Use Only.
Gosogliptin (PF-734200, PF-00734200) is a potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.
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Gosogliptin (PF-734200, PF-00734200) is a potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.
Gosogliptin demonstrates >200-fold selectivity over other members of the DPP family (DPP-2, DPP-3, DPP-8, and DPP-9) and the related serine proteases, FAP, aminopeptidase P, and propyl oligopeptidase.
Gosogliptin shows potential treatment for type 2 diabetes.
| M.Wt | 366.417 | |
| Formula | C17H24F2N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ammirati MJ, et al. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1991-5.
2. Dai H, et al. Br J Clin Pharmacol. 2011 Jul;72(1):85-91.
3. Sharma R, et al. Drug Metab Dispos. 2012 Nov;40(11):2143-61.
4. Rosenstock J, et al. Diabet Med. 2011 Apr;28(4):464-9.
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