Gosogliptin dihydrochloride |CAS:869490-47-1 Probechem Biochemicals

Chemical Structure : Gosogliptin dihydrochloride

Gosogliptin dihydrochloride (PF-734200;PF 734200;PF734200;PF 00734200)

Catalog No.: PC-60517Not For Human Use, Lab Use Only.

Gosogliptin dihydrochloride (PF-00734200) is a potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.

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Biological Activity

Gosogliptin dihydrochloride (PF-00734200) is a potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM.
Gosogliptin demonstrates >200-fold selectivity over other members of the DPP family (DPP-2, DPP-3, DPP-8, and DPP-9) and the related serine proteases, FAP, aminopeptidase P, and propyl oligopeptidase.
Gosogliptin shows potential treatment for type 2 diabetes.

Physicochemical Properties

M.Wt	439.333
Formula	C17H26Cl2F2N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone dihydrochloride

References

1. Ammirati MJ, et al. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1991-5.

2. Dai H, et al. Br J Clin Pharmacol. 2011 Jul;72(1):85-91.

3. Sharma R, et al. Drug Metab Dispos. 2012 Nov;40(11):2143-61.

4. Rosenstock J, et al. Diabet Med. 2011 Apr;28(4):464-9.

Gosogliptin dihydrochloride (PF-734200;PF 734200;PF734200;PF 00734200)

Biological Activity

Physicochemical Properties

References

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