Govorestat (AT-007) | Aldose Reductase inhibitor

Chemical Structure : Govorestat

CAS No.: 2170729-29-8

Govorestat (AT-007, AT007)

Catalog No.: PC-38679Not For Human Use, Lab Use Only.

Govorestat (AT-007) is a potent, selective, CNS-penetrant aldose reductase (aldehyde reductase) inhibitor with IC50 of 0.1 nM, reduces toxic galactitol levels and prevents galactosemia disease complications in vivo.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$348	In stock
50 mg	$558	In stock
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Biological Activity

Govorestat (AT-007) is a potent, selective, CNS-penetrant aldose reductase (aldehyde reductase) inhibitor with IC50 of 0.1 nM, reduces toxic galactitol levels and prevents galactosemia disease complications in vivo.

Physicochemical Properties

M.Wt	425.41
Formula	C17H10F3N3O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]thieno[3,4-d]pyridazine-1-acetic acid

References

1. Bhooshan N, et al. Lung Cancer. 2016 Nov;101:88-91.

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Govorestat (AT-007, AT007)

Biological Activity

Physicochemical Properties

References

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