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Govorestat

Chemical Structure : Govorestat

CAS No.: 2170729-29-8

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Govorestat (AT-007, AT007)

Catalog No.: PC-38679Not For Human Use, Lab Use Only.

Govorestat (AT-007) is a potent, selective, CNS-penetrant aldose reductase (aldehyde reductase) inhibitor with IC50 of 0.1 nM, reduces toxic galactitol levels and prevents galactosemia disease complications in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Govorestat (AT-007) is a potent, selective, CNS-penetrant aldose reductase (aldehyde reductase) inhibitor with IC50 of 0.1 nM, reduces toxic galactitol levels and prevents galactosemia disease complications in vivo.

Physicochemical Properties

M.Wt 425.41
Formula C17H10F3N3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]thieno[3,4-d]pyridazine-1-acetic acid

References

1. Bhooshan N, et al. Lung Cancer. 2016 Nov;101:88-91.

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