Chemical Structure : Gue-1654
CAS No.:
397290-30-1
Gue-1654
(Gue 1654;Gue1654)
Catalog No.: PC-70005Not For Human Use, Lab Use Only.
Gue-1654 (GUE 1654) is a small-molecule that inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R (Oxoeicosanoid receptor) in both recombinant and human primary cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Gue-1654 (GUE 1654) is a small-molecule that inhibits Gβγ but not Gα signaling triggered upon activation of Gα(i)-βγ by the chemoattractant receptor OXE-R (Oxoeicosanoid receptor) in both recombinant and human primary cells.
Gue-1654 blocks β-arrestin2 recruitment in HEK293 cells overexpressing OXE-R and ERK1/2 phosphorylation in human eosinophils and neutrophils.
Gue-1654 is the first small-molecule inhibitor for the oxoeicosanoid receptor (OXE-R) and the first probe to uncouple Gα and Gβγ signaling within a heterotrimer for any GPCR.
Physicochemical Properties
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M.Wt
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447.589
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Formula
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C23H17N3OS3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(7-(methylthio)benzo[1,2-d:4,3-d']bis(thiazole)-2-yl)-2,2-diphenylacetamide
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References
1. Blättermann S, et al. Nat Chem Biol. 2012 Jul;8(7):631-8.
2. Konya V, et al. J Immunol. 2014 May 15;192(10):4774-82.
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