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H2L5186303

Chemical Structure : H2L5186303

CAS No.: 139262-76-3

H2L5186303 (H2L 5186303)

Catalog No.: PC-49229Not For Human Use, Lab Use Only.

H2L5186303 is a potent, selective LPA2 receptor antagonist with IC50 of 8.9 nM, no significant activity against LPA1 and LPA3 receptors (IC50>1,000 nM), inhibits LPA(2) mediated Erk activation and proliferation of HCT-116 cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

H2L5186303 is a potent, selective LPA2 receptor antagonist with IC50 of 8.9 nM, no significant activity against LPA1 and LPA3 receptors (IC50>1,000 nM), inhibits LPA(2) mediated Erk activation and proliferation of HCT-116 cells.

Physicochemical Properties

M.Wt 488.452
Formula C26H20N2O8
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-Butenoic acid, 4,4′-[1,3-phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-, (Z,Z)-

References

1. Hilary P Beck, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41.

2. Chabowski DS, et al. Br J Pharmacol. 2018 Nov;175(22):4266-4280.

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