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Chemical Structure : H3B-616
Catalog No.: PC-38213Not For Human Use, Lab Use Only.
H3B-616 (H3B 616) is a potent, selective allosteric inhibitor of carbamoyl phosphate synthetase 1 (CPS1) with IC50 of 66 nM, demonstrates no appreciable inhibition of CPS2 (IC50>100 uM).
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H3B-616 (H3B 616) is a potent, selective allosteric inhibitor of carbamoyl phosphate synthetase 1 (CPS1) with IC50 of 66 nM, demonstrates no appreciable inhibition of CPS2 (IC50>100 uM).
H3B-616 demonstrated robust cellular inhibition of CPS1 with IC50 of 0.24 uM in cellular assays.
H3B-616 also showed a significant improvement in human hepatocyte stability (8.7 vs 35 μL/min/10-6 cells), favorable permeability (Caco2 A-B=12.3 × 10–6 cm/s), and good kinetic solubility (148 μM, pH 7.4).
| M.Wt | 409.461 | |
| Formula | C23H24FN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rolfe A, et al. ACS Med Chem Lett. 2020 May 26;11(6):1305-1309.
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