Catalog No.: PC-42156Not For Human Use, Lab Use Only.
HA-15 is a specifc inhibitor of the chaperone BiP (Binding immunoglobulin protein, GRP78 or HSPA5) that displays anti-cancerous activity on melanoma cells, including BRAF resistance melanoma cells.
HA-15 is a specifc inhibitor of the chaperone BiP (Binding immunoglobulin protein, GRP78 or HSPA5) that displays anti-cancerous activity on melanoma cells, including BRAF resistance melanoma cells.
HA-15 does not interact with IRE1α, ATF6, or HSP70, increases ER stress and induces autophagy and apoptosis.
HA-15 exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitor.
