HA-CD44 inhibitor JE22

Chemical Structure : HA-CD44 inhibitor JE22

Catalog No.: PC-27535Not For Human Use, Lab Use Only.

HA-CD44 inhibitor JE22 is a small molecule Hyaluronic acid (HA)-CD44 interaction inhibitor, effectively blocks HA-CD44 binding, shows antiproliferative activity with EC50 of 8 uM against the CD44+ breast cancer tumor line MDA-MB-231.

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Biological Activity

Physicochemical Properties

M.Wt	203.29
Formula	C13H17NO
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,4-dihydroisoquinolin-2(1H)-yl)butan-2-one

References

1. Li-Kai Liu, et al. J Med Chem. 2014 Mar 27;57(6):2714-25.

2. Espejo-Román JM, et al. Eur J Med Chem. 2023;258:115570.

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