Catalog No.: PC-21246Not For Human Use, Lab Use Only.
HAMNO (NSC 111847) is a small molecule protein interaction inhibitor of replication protein A (RPA), specifically inhibits RPA DNA binding domain F (DBD-F), inhibits dsDNA unwinding with IC50 of 9 uM.
HAMNO (NSC 111847) is a small molecule protein interaction inhibitor of replication protein A (RPA), specifically inhibits RPA DNA binding domain F (DBD-F), inhibits dsDNA unwinding with IC50 of 9 uM. HAMNO (NSC 111847) is selective for inhibiting only DBD-F, but not DBDs A-E which are important in RPA binding to ssDNA. HAMNO (NSC 111847) selectively binds the N-terminal domain of RPA70, effectively inhibiting critical RPA protein interactions. HAMNO (NSC 111847) induces γ-H2AX staining in a cell-cycle specific manner, alters RPA32 and ATR phosphorylation. HAMNO (NSC 111847) inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO (NSC 111847) enhances etoposide toxicity, HAMNO (NSC 111847) (1mg/kg) slowed the progression of UMSCC11B tumors in mouse xenograft model.
