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HATC

Chemical Structure : HATC

CAS No.:

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HATC (HIF-1α-targeting autophagy-tethering compound)

Catalog No.: PC-26775Not For Human Use, Lab Use Only.

HATC is a small-molecule HIF-1α-targeting autophagy-tethering compound that degrade hypoxia-inducible factor-1α (HIF-1α), HATC reduces HIF-1α levels across multiple organs, ameliorates a range of age-related pathologies and significantly extended both median and maximum lifespan.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HATC is a small-molecule HIF-1α-targeting autophagy-tethering compound that degrade hypoxia-inducible factor-1α (HIF-1α), HATC reduces HIF-1α levels across multiple organs, ameliorates a range of age-related pathologies and significantly extended both median and maximum lifespan.

Physicochemical Properties

M.Wt 1463.19
Formula C78H100ClN13O13
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1-(4-(((2S,5S,8S,11S,14S,17S)-11-benzyl-17-(4-hydroxybenzyl)-5,8-diisobutyl-14-isopropyl-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexaazacyclooctadecan-2-yl)methyl)-1H-1,2,3-triazol-1-yl)-12-oxo-3,6,9-trioxa-13-azahexadecan-16-yl)-N-((R)-1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)benzamide

References

1. Yang C, et al. Nat Aging. 2026 May 12. doi: 10.1038/s43587-026-01124-z.

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