Chemical Structure : HBS-101
CAS No.:
HBS-101
(HBS101)
Catalog No.: PC-24528Not For Human Use, Lab Use Only.
HBS-101 is a potent, specific midkine (MDK) inhibitor, disrupts MDK's binding to its endogenous receptors, significantly reduces cell viability of triple negative breast cancer (TNBC) (IC50 0.3-2.8 µM), clonogenic survival, invasiveness, and increased apoptosis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HBS-101 is a potent, specific midkine (MDK) inhibitor, disrupts MDK's binding to its endogenous receptors, significantly reduces cell viability of triple negative breast cancer (TNBC) (IC50 0.3-2.8 µM), clonogenic survival, invasiveness, and increased apoptosis.
HBS-101 exhibits distinct pharmacologic advantages, including oral bioavailability, blood-brain-barrier penetration, and in vivo stability.
The underlying mechanism of HBS-101 involves suppression of Akt/mTOR, STAT3, and NF-B pathways.
HBS-101 inhibits growth of TNBC patient-derived xenograft tumors in vivo and markedly reduced TNBC brain-metastatic-tumor growth and prolonged mice survival.
Physicochemical Properties
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M.Wt
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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