HBS-101 | Midkine inhibitor | Probechem Biochemicals

Chemical Structure : HBS-101

HBS-101 (HBS101)

Catalog No.: PC-24528Not For Human Use, Lab Use Only.

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Biological Activity

HBS-101 is a potent, specific midkine (MDK) inhibitor, disrupts MDK's binding to its endogenous receptors, significantly reduces cell viability of triple negative breast cancer (TNBC) (IC50 0.3-2.8 µM), clonogenic survival, invasiveness, and increased apoptosis.
HBS-101 exhibits distinct pharmacologic advantages, including oral bioavailability, blood-brain-barrier penetration, and in vivo stability.
The underlying mechanism of HBS-101 involves suppression of Akt/mTOR, STAT3, and NF-B pathways.
HBS-101 inhibits growth of TNBC patient-derived xenograft tumors in vivo and markedly reduced TNBC brain-metastatic-tumor growth and prolonged mice survival.

Physicochemical Properties

M.Wt	346.42
Formula	C21H24F2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(13S,17S)-17-(1,1-difluoroprop-2-yn-1-yl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

References

1. Mahajan M, et al. Mol Cancer Ther. 2025 Apr 30. doi: 10.1158/1535-7163.MCT-25-0130.

HBS-101 (HBS101)

Biological Activity

Physicochemical Properties

References

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