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HBX-90659

Chemical Structure : HBX-90659

CAS No.: 924296-19-5

HBX-90659 (HBX90659, compound 22e, USP8-IN-22e)

Catalog No.: PC-72535Not For Human Use, Lab Use Only.

HBX-90659 (compound 22 e) is a potent, selective USP8 inhibitor with IC50 of 0.28 uM, with no effect on USP7 (IC50 of >100 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HBX-90659 (compound 22 e) is a potent, selective USP8 inhibitor with IC50 of 0.28 uM, with no effect on USP7 (IC50 of >100 uM).
HBX-90659 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 uM.

Physicochemical Properties

M.Wt 275.27
Formula C15H9N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

9-(Ethoxyimino)-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

References

1. Matteo Colombo, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.

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