HBX-90659 | USP8 inhibitor | Probechem Biochemicals

Chemical Structure : HBX-90659

CAS No.: 924296-19-5

HBX-90659 (HBX90659, compound 22e, USP8-IN-22e, DUB-IN-2)

Catalog No.: PC-72535Not For Human Use, Lab Use Only.

HBX-90659 (compound 22e, DUB-IN-2) is a potent, selective USP8 inhibitor with IC50 of 0.28 uM, with no effect on USP7 (IC50 of >100 uM).

Packing	Price	Stock
5 mg	$158	In stock
10 mg	$248	In stock
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Biological Activity

HBX-90659 (compound 22e, DUB-IN-2) is a potent, selective USP8 inhibitor with IC50 of 0.28 uM, with no effect on USP7 (IC50 of >100 uM).
HBX-90659 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 uM.

Physicochemical Properties

M.Wt	275.27
Formula	C15H9N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-(Ethoxyimino)-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

References

1. Matteo Colombo, et al. ChemMedChem. 2010 Apr 6;5(4):552-8.

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HBX-90659 (HBX90659, compound 22e, USP8-IN-22e, DUB-IN-2)

Biological Activity

Physicochemical Properties

References

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