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Chemical Structure : HC-030031
CAS No.: 349085-38-7
Catalog No.: PC-21579Not For Human Use, Lab Use Only.
HC-030031 is a potent, selective TRPA1 inhibitor, inhibits AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote | ||
| 200 mg | Get quote | ||
| 1 g | Get quote |
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HC-030031 is a potent, selective TRPA1 inhibitor, inhibits AITC- and formalin-evoked calcium influx with IC50 of 6.2 and 5.3 μM, respectively.
HC-030031 does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels.
HC-030031 inhibition of TRPA1 attenuates formalin- and AITC-evoked pain behavior.
HC-030031 blocks formalin-evoked responses in vivo.
| M.Wt | 355.40 | |
| Formula | C18H21N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(1,3-Dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)-N-(4-isopropylphenyl)acetamide |
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1. Taylor-Clark TE, et al. Mol Pharmacol. 2008 Feb;73(2):274-81.
2. Eid SR, et al. Mol Pain. 2008 Oct 27;4:48.
3. Colleen R McNamara, et al. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13525-30.
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