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Chemical Structure : HCH6-1
CAS No.: 1435265-06-7
Catalog No.: PC-20392Not For Human Use, Lab Use Only.
HCH6-1 is a selective, competitive formyl peptide receptor 1 (FPR1) antagonist, superoxide anion generation in fMLF (FPR1 agonist)-activated neutrophils with IC50 of 0.32 uM in cell-impermeable cytochrome c reduction assay.
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|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $488 | In stock | |
| 100 mg | Get quote |
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HCH6-1 is a selective, competitive formyl peptide receptor 1 (FPR1) antagonist, superoxide anion generation in fMLF (FPR1 agonist)-activated neutrophils with IC50 of 0.32 uM in cell-impermeable cytochrome c reduction assay.
HCH6-1 inhibits superoxide anion generation, elastase release, and chemotaxis in human neutrophils specifically activated by fMLF.
HCH6-1 significantly inhibits elastase release in fMLF-activated neutrophils with IC50 of 0.57 uM.
HCH6-1 reduces inflammatory cell infiltration and distortion of pulmonary architecture in the presence of LPS. HCH6-1 posttreatment shows inhibitory effects on neutrophil accumulation and lung damage in LPS-induced ALI mice
| M.Wt | 469.54 | |
| Formula | C28H27N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
methyl benzoyl-L-tryptophyl-D-phenylalaninate |
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1. Hung-Li Wang, et al. Biochem Pharmacol. 2023 Mar 29;115524.
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