Catalog No.: PC-20392Not For Human Use, Lab Use Only.
HCH6-1 is a selective, competitive formyl peptide receptor 1 (FPR1) antagonist, superoxide anion generation in fMLF (FPR1 agonist)-activated neutrophils with IC50 of 0.32 uM in cell-impermeable cytochrome c reduction assay.
HCH6-1 is a selective, competitive formyl peptide receptor 1 (FPR1) antagonist, superoxide anion generation in fMLF (FPR1 agonist)-activated neutrophils with IC50 of 0.32 uM in cell-impermeable cytochrome c reduction assay.
HCH6-1 inhibits superoxide anion generation, elastase release, and chemotaxis in human neutrophils specifically activated by fMLF.
HCH6-1 significantly inhibits elastase release in fMLF-activated neutrophils with IC50 of 0.57 uM.
HCH6-1 reduces inflammatory cell infiltration and distortion of pulmonary architecture in the presence of LPS. HCH6-1 posttreatment shows inhibitory effects on neutrophil accumulation and lung damage in LPS-induced ALI mice
Physicochemical Properties
M.Wt
469.54
Formula
C28H27N3O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
methyl benzoyl-L-tryptophyl-D-phenylalaninate
References
1. Hung-Li Wang, et al. Biochem Pharmacol. 2023 Mar 29;115524.
