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HCI-2389

Chemical Structure : HCI-2389

CAS No.:

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HCI-2389 (HCI2389)

Catalog No.: PC-61484Not For Human Use, Lab Use Only.

HCI-2389 is a potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HCI-2389 is a potent, specific, irreversible NIMA-related Kinase 2 (NEK2) inhibitor with IC50 of 16.65 nM.
    HCI-2389 significantly decreases level of phosphorylated PP1-α in HeLa cellsat 10 nM, significantly increases the effectiveness of bortezomib in inhibiting proteasome activity at concentrations as low as 10 nM.
    HCI-2389 inhibits the degradation of Cyclin B and Cdc2, successfully mitigates drug resistance in bortezomib-resistant multiple myeloma.

    Physicochemical Properties

    M.Wt 571.097
    Formula C26H31ClN8O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-((5-chloro-4-((2-(N,N-dimethylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)-2-(4-methylpiperazin-1-yl)phenyl)acrylamide

    References

    1. Meng L, et al. Biomed Res Int. 2014;2014:273180.

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