Catalog No.: PC-73287Not For Human Use, Lab Use Only.
HDAC8 PROTAC 1 is a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8) with DC50 of 0.7 uM in T-cell leukemia Jurkat cells.
HDAC8 PROTAC 1 is a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8) with DC50 of 0.7 uM in T-cell leukemia Jurkat cells.
HDAC8 PROTAC 1 does not influence the levels of HDAC1, HDAC2, and HDAC6.
HDAC8 PROTAC 1 strongly inhibits Jurkat cell growth with a GI50 value of 0.78 μM
HDAC8 PROTAC 1 induced degradation of HDAC8 without affecting the levels of other HDACs in cellular assays, and inhibited the growth of T-cell leukemia Jurkat cells more potently than a conventional HDAC8 inhibitor.
HDAC8 PROTAC 1 degrades HDAC8 via PROTAC-mediated UPS
