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Chemical Structure : HDAC8 PROTAC 1
CAS No.:
Catalog No.: PC-73287Not For Human Use, Lab Use Only.
HDAC8 PROTAC 1 is a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8).
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HDAC8 PROTAC 1 is a first-in-class proteolysis targeting chimera (PROTAC) for selective degradation of histone deacetylase 8 (HDAC8).
HDAC8 PROTAC 1 induced degradation of HDAC8 without affecting the levels of other HDACs in cellular assays, and inhibited the growth of T-cell leukemia Jurkat cells more potently than a conventional HDAC8 inhibitor.
| M.Wt | 794.928 | |
| Formula | C41H46N8O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecyl)-3-(((1-(3-(hydroxycarbamoyl)phenyl)-1H-1,2,3-triazol-4-yl)methyl)thio)benzamide |
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1. Jiranan Chotitumnavee, et al. Chem Commun (Camb). 2022 Apr 7;58(29):4635-4638.
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