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Chemical Structure : HEI3090
Catalog No.: PC-72592Not For Human Use, Lab Use Only.
HEI3090 (HEI-3090) is a small-molecule P2RX7 activator (positive modulator) of purinergic P2RX7 receptor (P2X7R), enhances the P2RX7-mediated intracellular calcium concentration (Emax=250 nM).
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HEI3090 (HEI-3090) is a small-molecule P2RX7 activator (positive modulator) of purinergic P2RX7 receptor (P2X7R), enhances the P2RX7-mediated intracellular calcium concentration (Emax=250 nM).
HEI3090 inhibits tumor growth and combined with αPD-1 immunotherapy ameliorates mice survival.
Dendritic cells (DCs) mediate the antitumor activity induced by HEI3090.
HEI3090 induces the production of mature IL-18 in the presence of eATP, triggers antitumor responses mediated by IL-18-induced NK and CD4+ T cells.
HEI3090 combined with αPD-1 induces antitumor memory immune response.
| M.Wt | 441.693 | |
| Formula | C18H15Cl3N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (4.4 mg/mL) |
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1. Laetitia Douguet, et al. Nat Commun. 2021 Jan 28;12(1):653.
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