HEI3090 (HEI-3090) is a small-molecule P2RX7 activator (positive modulator) of purinergic P2RX7 receptor (P2X7R), enhances the P2RX7-mediated intracellular calcium concentration (Emax=250 nM).
HEI3090 inhibits tumor growth and combined with αPD-1 immunotherapy ameliorates mice survival.
Dendritic cells (DCs) mediate the antitumor activity induced by HEI3090.
HEI3090 induces the production of mature IL-18 in the presence of eATP, triggers antitumor responses mediated by IL-18-induced NK and CD4+ T cells.
HEI3090 combined with αPD-1 induces antitumor memory immune response.
