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Chemical Structure : HF50731
Catalog No.: PC-72032Not For Human Use, Lab Use Only.
HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.
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HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.
HF50731 significantly inhibited SDF-1α-induced calcium mobilization (IC50=621 nM) and cell migration, and blocked HIV-1 infection via antagonizing CXCR4 coreceptor function (IC50=1.5 uM).
The structure-activity relationship analysis demonstrated that HF50731 could primarily occupy the minor subpocket of CXCR4 and partially bind in the major subpocket by interacting with residues W94, D97, D171, and E288.
| M.Wt | 414.682 | |
| Formula | C26H46N4 | |
| Appearance | Solid | |
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1. Xiong Fang, et al. Eur J Med Chem. 2020 Aug 15;200:112410.
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