HI-B1 is a small molecule inhibitor of β-catenin/TCF4 interaction, directly targets β-catenin and disrupts β-catenin/TCF4 complex formation. HI-B1 suppresses growth of several types of colon cancer cells (DLD1, CACO2 and HCT116), but did not affect the H838 lung cancer cell line, preferentially kills cancer cells in which β-catenin is critical for survival. HI-B1 directly binds with β-catenin and disrupts the β-catenin/TCF4 interaction HI-B1 (50 mg/kg, oral) inhibits β-catenin-driven tumorigenesis in PDX colon cancer models.
Physicochemical Properties
M.Wt
255.30
Formula
C15H14FN3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
CN(C)C1=CC=C(C2=NC3=CC(F)=CC=C3N2)C=C1
References
1. Seung Ho Shin, et al. EBioMedicine. 2017 Nov;25:22-31.
