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Chemical Structure : HI-TOPK-032
CAS No.: 487020-03-1
Catalog No.: PC-42404Not For Human Use, Lab Use Only.
HI-TOPK-032 is a novel potent, specific TOPK inhibitor that has no effect on ERK1, JNK1, or p38 kinase activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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HI-TOPK-032 is a novel potent, specific TOPK inhibitor that has no effect on ERK1, JNK1, or p38 kinase activity.
HI-TOPK-032 also weakly inhibits MEK1 (40% inhibition at 5 uM).
HI-TOPK-032 inhibits anchorage-dependent and -independent colon cancer cell growth by reducing ERK-RSK phosphorylation.
HI-TOPK-032 suppresses tumor growth in a colon cancer xenograft model.
| M.Wt | 369.4 | |
| Formula | C20H11N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥7.5 mg/mL |
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| Chemical Name/SMILES |
2-Thiophenecarboxamide, N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)- |
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1. Kim DJ, et al. Cancer Res. 2012 Jun 15;72(12):3060-8.
2. Joel M, et al. Mol Cancer. 2015 Jun 17;14:121.
3. Wang MY, et al. Oncotarget. 2016 May 3;7(18):26604-16.
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