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HI-TOPK-032

Chemical Structure : HI-TOPK-032

CAS No.: 487020-03-1

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HI-TOPK-032 (HI TOPK 032;HI-TOPK032)

Catalog No.: PC-42404Not For Human Use, Lab Use Only.

HI-TOPK-032 is a novel potent, specific TOPK inhibitor that has no effect on ERK1, JNK1, or p38 kinase activity.

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10 mg $118 In stock
25 mg $198 In stock
50 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HI-TOPK-032 is a novel potent, specific TOPK inhibitor that has no effect on ERK1, JNK1, or p38 kinase activity.
HI-TOPK-032 also weakly inhibits MEK1 (40% inhibition at 5 uM).
HI-TOPK-032 inhibits anchorage-dependent and -independent colon cancer cell growth by reducing ERK-RSK phosphorylation.
HI-TOPK-032 suppresses tumor growth in a colon cancer xenograft model.

Physicochemical Properties

M.Wt 369.4
Formula C20H11N5OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥7.5 mg/mL
Chemical Name/SMILES

2-Thiophenecarboxamide, N-(12-cyanoindolizino[2,3-b]quinoxalin-2-yl)-

References

1. Kim DJ, et al. Cancer Res. 2012 Jun 15;72(12):3060-8.

2. Joel M, et al. Mol Cancer. 2015 Jun 17;14:121.

3. Wang MY, et al. Oncotarget. 2016 May 3;7(18):26604-16.

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