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HIF2α inhibitor Compound-c2

Chemical Structure : HIF2α inhibitor Compound-c2

CAS No.: 861212-49-9

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HIF2α inhibitor Compound-c2

Catalog No.: PC-25968Not For Human Use, Lab Use Only.

HIF2α inhibitor Compound-c2 is a selective HIF2α inhibitor that binds to the PAS-B domain of HIF2α, disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to proteasomal degradation of HIF2α and the induction of apoptosis in ccRCC.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HIF2α inhibitor Compound-c2 is a selective HIF2α inhibitor that binds to the PAS-B domain of HIF2α, disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to proteasomal degradation of HIF2α and the induction of apoptosis in ccRCC.

Physicochemical Properties

M.Wt 311.32
Formula C17H14FN3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-N-(3-ethyl-2-oxo-2,3-dihydroquinazolin-4(1H)-ylidene)-4-fluorobenzamide

References

1. Heritz JA, et al. Commun Med (Lond). 2026 Jan 12. doi: 10.1038/s43856-025-01356-x.

2. Patent WO2025091029 A1.

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