HIF2α inhibitor Compound-c2

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Chemical Structure : HIF2α inhibitor Compound-c2

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Catalog No.: PC-25968Not For Human Use, Lab Use Only.

HIF2α inhibitor Compound-c2 is a selective HIF2α inhibitor that binds to the PAS-B domain of HIF2α, disrupts the interaction between HIF2α and the molecular chaperone Hsp70, leading to proteasomal degradation of HIF2α and the induction of apoptosis in ccRCC.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	311.32
Formula	C17H14FN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-N-(3-ethyl-2-oxo-2,3-dihydroquinazolin-4(1H)-ylidene)-4-fluorobenzamide

References

1. Heritz JA, et al. Commun Med (Lond). 2026 Jan 12. doi: 10.1038/s43856-025-01356-x.

2. Patent WO2025091029 A1.

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