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HJC0197

Chemical Structure : HJC0197

CAS No.: 1383539-73-8

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HJC0197 (HJC-0197)

Catalog No.: PC-63108Not For Human Use, Lab Use Only.

HJC0197 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 4.0 uM.

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5 mg $88 In stock
10 mg $138 In stock
25 mg $248 In stock
50 mg $398 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HJC0197 is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor with IC50 of 4.0 uM.
HJC0197 also inhibits EPAC1-mediated Rap1-GDP exchange activity.
HJC0197 does not alter cAMP-induced type I and II PKA holoenzymes activation at 25 uM.

Physicochemical Properties

M.Wt 339.457
Formula C19H21N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-cyclopentyl-2-((2,5-dimethylbenzyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

References

1. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65.

2. Chen H, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.

3. Juhász T, et al. Cell Signal. 2014 Mar;26(3):468-82.

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