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HJC0338

Chemical Structure : HJC0338

CAS No.: 1417718-39-8

HJC0338 (HJC-0338)

Catalog No.: PC-63110Not For Human Use, Lab Use Only.

HJC0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HJC0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2.
    HJC0338 exhibits no inhibition of EPAC1-mediated Rap1-GDP exchange activity at 25 uM.
    HJC0338 selectively block cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation.

    Physicochemical Properties

    M.Wt 280.192
    Formula C15H15Cl2N
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (2,5-Dichloro-phenyl)-(2,4,6-trimethyl-phenyl)-amine

    References

    1. Chen H, et al. J Med Chem. 2013 Feb 14;56(3):952-62.

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