HJC0338 | EPAC2 antagonist | Probechem Biochemicals

Chemical Structure : HJC0338

HJC0338 (HJC-0338)

Catalog No.: PC-63110Not For Human Use, Lab Use Only.

HJC0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2.

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Biological Activity

HJC0338 is a potent and specific EPAC2 antagonist with IC50 of 0.4 uM for competing with 8-NBD-cAMP in binding EPAC2.
HJC0338 exhibits no inhibition of EPAC1-mediated Rap1-GDP exchange activity at 25 uM.
HJC0338 selectively block cAMP-induced EPAC2 activation but do not inhibit cAMP-mediated PKA activation.

Physicochemical Properties

M.Wt	280.192
Formula	C15H15Cl2N
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2,5-Dichloro-phenyl)-(2,4,6-trimethyl-phenyl)-amine

References

1. Chen H, et al. J Med Chem. 2013 Feb 14;56(3):952-62.

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HJC0338 (HJC-0338)

Biological Activity

Physicochemical Properties

References

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