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HL389

Chemical Structure : HL389

CAS No.:

HL389 (HL-389)

Catalog No.: PC-22414Not For Human Use, Lab Use Only.

HL389 is a molecular glue acting as recruitment moiety for CRL4 DCAF11 and could be used for developed alkenyl oxindole-based PROTAC molecules.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HL389 is a molecular glue acting as recruitment moiety for CRL4 DCAF11 and could be used for developed alkenyl oxindole-based PROTAC molecules.

Physicochemical Properties

M.Wt 498.30
Formula C22H19BrF3NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

tert-butyl (Z)-2-(4-bromo-2-((2-oxo-6-(trifluoromethyl)indolin-3-ylidene)methyl)phenoxy)acetate

References

1. Wang Y, et al. PLoS Biol. 2024 May 20;22(5):e3002550.

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