Catalog No.: PC-35141Not For Human Use, Lab Use Only.
HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively).
HMS-101 (HMS101) is a potent, selective mutant IDH1 inhibitor, the IC50 is significantly lower in mouse bone marrow cells transduced with IDH1mut compared with IDH1wt (1 uM vs 12 uM, respectively).
HMS-101 binds to the isocitrate-binding pocket of mutant IDH1, significantly reduces intracellular R-2HG levels in vitro HoxA9+IDH1mut cells at 10 uM.
HMS-101 induces apoptosis in IDH1mut cells, markedly reduces phospho-ERK1/2 and the ratio of phospho-ERK/total-ERK, inhibits human AML cell growth.
