HNF4α agonist (Z)-19 is a small molecule agonist of hepatocyte nuclear factor 4 alpha (HNF4α) with EC50 of 9.2 uM and SPR KD of 4.6 uM. (Z)-19 reduced triglyceride and total cholesterol accumulation with minimal cytotoxicity and exhibited ferroptosis-protective activity in HepG2 cells. (Z)-19 lowered plasma triglyceride and total cholesterol levels in hyperlipidemia mouse model, indicating encouraging in vivo efficacy.
