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HR22C16

Chemical Structure : HR22C16

CAS No.: 462630-41-7

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HR22C16 (trans-HR22C16, Monastroline)

Catalog No.: PC-70047Not For Human Use, Lab Use Only.

HR22C16 (Monastroline) is a potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HR22C16 (Monastroline) is a potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins.
    HR22C16 (Monastroline) inhibits cell survival in both Taxol-sensitive and -resistant ovarian cancer cells with at least 15-fold greater efficacy than monastrol.

    Physicochemical Properties

    M.Wt 389.455
    Formula C23H23N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-butyl-5-(3-hydroxyphenyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione

    References

    1. Hotha S, et al. Angew Chem Int Ed Engl. 2003 May 30;42(21):2379-82.

    2. Marcus AI, et al. J Biol Chem. 2005 Mar 25;280(12):11569-77.

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