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Chemical Structure : HSF1A
Catalog No.: PC-61302Not For Human Use, Lab Use Only.
A small molecule human HSF1 (heat shock transcription factor 1) activator.
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A small molecule human HSF1 (heat shock transcription factor 1) activator; activates HSF1 in mammalian and fly cells, elevates protein chaperone expression, ameliorates protein misfolding and cell death in polyQ-expressing neuronal precursor cells and protects against cytotoxicity in a fly model of polyQ-mediated neurodegeneration; also interacts with components of the TRiC/CCT complex.
| M.Wt | 409.522 | |
| Formula | C21H19N3O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Neef DW, et al. PLoS Biol. 2010 Jan 19;8(1):e1000291.
2. Bocchini CE, et al. Blood. 2016 Dec 29;128(26):3061-3072.
3. Huang CY, et al. Cell Death Dis. 2016 Nov 3;7(11):e2455.
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