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Chemical Structure : HSP70-IN-27c
CAS No.: 1268273-90-0
Catalog No.: PC-43120Not For Human Use, Lab Use Only.
HSP70-IN-27c is a potent, irreversible inhibitor of Hsp70 without Hsp 90 binding activity, inhibits growth of Kasumi-1 AML cells with IC50 of 2.3 uM, and inhibits Caspase-3,7 activation in MOLM13 AML cells with IC50 of 1.9 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $238 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $548 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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HSP70-IN-27c is a potent, irreversible inhibitor of Hsp70 without Hsp 90 binding activity, inhibits growth of Kasumi-1 AML cells with IC50 of 2.3 uM, and inhibits Caspase-3,7 activation in MOLM13 AML cells with IC50 of 1.9 uM.
HSP70-IN-27c inhibits HER2 and Raf-1 steady-state levels, PARP cleavage in SKBr3 breast cancer cells with IC50 of about 1.5 uM.
HSP70-IN-27c induces apoptosis in MDA-MB-468 cells.
| M.Wt | 464.5831 | |
| Formula | C24H28N6O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Acetamide, 2-amino-N-[3-[[2-(4-methyl-1-piperazinyl)-4-(phenylmethoxy)-5-pyrimidinyl]thio]phenyl]- |
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1. Taldone T, et al. J Med Chem. 2014 Feb 27;57(4):1208-24.
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