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HSP70 modulator 115-7c

Chemical Structure : HSP70 modulator 115-7c

CAS No.: 908074-72-6

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HSP70 modulator 115-7c (Compound 115-7c)

Catalog No.: PC-62353Not For Human Use, Lab Use Only.

HSP70 modulator 115-7c is an artificial co-chaperone, enhancer of Hsp70, stimulats the ATPase and protein-folding activities of a prokaryotic Hsp70 (DnaK) and partially compensated for a Hsp40 loss-of-function mutation in yeast.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HSP70 modulator 115-7c is an artificial co-chaperone, enhancer of Hsp70, stimulats the ATPase and protein-folding activities of a prokaryotic Hsp70 (DnaK) and partially compensated for a Hsp40 loss-of-function mutation in yeast.
    115-7c decreases α-syn aggregation in neuroglioma cells.

    Physicochemical Properties

    M.Wt 477.34
    Formula C23H22Cl2N2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(5-((benzyloxy)carbonyl)-4-(2,4-dichlorophenyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanoic acid

    References

    1. Wisén S, et al. ACS Chem Biol. 2010 Jun 18;5(6):611-22.

    2. Kilpatrick K, et al. ACS Chem Biol. 2013 Jul 19;8(7):1460-8.

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