HTHQ is a potent anti-oxidative agent that effectively scavenges t-butyl peroxyl radicals with IC50 of 0.31 mM (ROS inhibition).
HTHQ exerts chemopreventive effects against heterocyclic amine (HCA)-induced hepatocarcinogenesis.
HTHQ exhibits 4.8-fold higher anti-lipid-peroxidation activity than that of D,L-alpha-tocopherol, scavenges the lipid peroxides Fe3+ -ADP-induced lipid peroxidation in rat liver microsomes.
Physicochemical Properties
M.Wt
236.3499
Formula
C15H24O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Phenol, 4-(hexyloxy)-2,3,6-trimethyl-
References
1. Hirose M, et al. Jpn J Cancer Res. 1993 May;84(5):481-4.
2. Hirose M, et al. Carcinogenesis. 1995 Dec;16(12):3049-55.
3. An J, et al. Hepatol Res. 2010 Jun;40(6):613-21.
