HTRA1 inhibitor 17

Chemical Structure : HTRA1 inhibitor 17

Catalog No.: PC-22463Not For Human Use, Lab Use Only.

HTRA1 inhibitor 17 is a highly potent and selective inhibitor of high temperature requirement A serine peptidase 1 (HTRA1) serine protease with IC50 of 13 nM.

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Biological Activity

HTRA1 inhibitor 17 is a highly potent and selective inhibitor of high temperature requirement A serine peptidase 1 (HTRA1) serine protease with IC50 of 13 nM.
HTRA1 inhibitor 17 only weakly inhibits chymotrypsin, kallikrein 7, caspase 6 and caspase 9 in a panel of 35 proteases.

Physicochemical Properties

M.Wt	583.96
Formula	C31H43BClN3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	((R)-((S)-2-((S)-3-(3-chlorophenyl)-2-(2,2-dimethyl-3-phenylpropanamido)propanamido)-4-methylpentanamido)(cyclobutyl)methyl)boronic acid

References

1. Dennis DG, et al. Bioorg Med Chem Lett. 2024 May 28:129814.

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