Chemical Structure : HU-210
CAS No.:
112924-45-5
HU-210
(HU210)
Catalog No.: PC-22159Not For Human Use, Lab Use Only.
HU-211 is a functional N-methyl-D-aspartate receptor blocker with IC50 of 6-10 uM for glutamate- or glycine-induced binding.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HU-211 is a functional N-methyl-D-aspartate receptor blocker with IC50 of 6-10 uM for glutamate- or glycine-induced binding.
HU-211 is a synthetic terpene-based cannabinoid devoid of central cannabinoid (CB1) and peripheral cannabinoid (CB2) agonist activity.
HU-211 also has anti-inflammatory properties derived through inhibition of NF-κB and the resulting decreases in cytokines such as TNF-α and interleukin-6.
HU-211 induces stereotype and locomotor hyperactivity in mice and tachycardia in rat, effects typically caused by NMDA receptor antagonists.
HU-211 is also a potent blocker of NMDA-induced tremor, seizures, and lethality in mice.
Physicochemical Properties
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M.Wt
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386.58
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Formula
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C25H38O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(6aS,10aS)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
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References
1. Feigenbaum JJ, et al. Eur J Pharmacol. 1989 Oct 4;169(1):159-65.
2. Shohami E, et al. J Neurotrauma. 1993 Summer;10(2):109-19.
3. Feigenbaum JJ, et al. Proc Natl Acad Sci U S A. 1989 Dec;86(23):9584-7.
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