Chemical Structure : HU-308
CAS No.:
256934-39-1
HU-308
(HU308)
Catalog No.: PC-22234Not For Human Use, Lab Use Only.
HU-308 is a potent, selective cannabinoid CB2 receptor agonist with Ki of 22.7 nM in competition binding assay, does not bind to CB1 receptor.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HU-308 is a potent, selective cannabinoid CB2 receptor agonist with Ki of 22.7 nM in competition binding assay, does not bind to CB1 receptor.
HU-308 inhibits forskolin-stimulated cyclic AMP production in CB(2)-transfected cells, but does so much less in CB(1)-transfected cells.
HU-308 has IC50 of 117 nM in cAMP assays, EC50 of 18.3 nM in [35S]GTPγS binding assays.
HU-308 reduces blood pressure, blocks defecation, and elicits anti-inflammatory and peripheral analgesic activity in mice in a tetrad of behavioral tests.
Physicochemical Properties
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M.Wt
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414.62
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Formula
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C27H42O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-2-ene-2-methanol
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References
1. Hanus L, et al. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14228-33.
2. Ueda Y, et al. Eur J Pharmacol. 2005 Sep 27;520(1-3):164-71.
3. Horváth B, et al. Br J Pharmacol. 2012 Apr;165(8):2462-78.
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