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HW091077

Chemical Structure : HW091077

CAS No.: 2766757-55-3

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HW091077 (HW-091077)

Catalog No.: PC-25573Not For Human Use, Lab Use Only.

HW091077 is a potent, selective P2X3 receptor (P2X3R) antagonist with IC50 of 17 nM, shows balanced selectivity versus P2X2/3 (IC50=190 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HW091077 is a potent, selective P2X3 receptor (P2X3R) antagonist with IC50 of 17 nM, shows balanced selectivity versus P2X2/3 (IC50=190 nM).
HW091077 shows negligible antagonistic activity against other human P2X receptor subtypes, such as P2X1, P2X2, P2X4, P2X5, and P2X7, by calcium influx assays in HEK-293 cells.
HW091077 shows robust in vivo antitussives efficacy on citric acid/Histamine-induced cough in guinea pigs.

Physicochemical Properties

M.Wt 498.50
Formula C22H22F4N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Fluoro-5-(((2S,3R)-3-hydroxybutan-2-yl)oxy)-3-(5-methylthiazol-2-yl)-N-((R)-1-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)benzamide

References

1. Zang Y, et al. Eur J Med Chem. 2025 Sep 7;300:118116.

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