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HX531

Chemical Structure : HX531

CAS No.: 188844-34-0

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HX531 (HX 531)

Catalog No.: PC-20776Not For Human Use, Lab Use Only.

HX531 is a potent, pan RXR antagonist with IC50 of 18 nM on retinoidal activity in HL-60 cell assays, HX531 also is a partial PPARγ inhibitor and ameliorates diet-induced obesity and type 2 diabetes.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HX531 is a potent, pan RXR antagonist with IC50 of 18 nM on retinoidal activity in HL-60 cell assays, HX531 also is a partial PPARγ inhibitor and ameliorates diet-induced obesity and type 2 diabetes.

Physicochemical Properties

M.Wt 483.57
Formula C29H29N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid

References

1. M Ebisawa, et al. Chem Pharm Bull (Tokyo). 1999 Dec;47(12):1778-86.

2. T Yamauchi, et al. J Clin Invest. 2001 Oct;108(7):1001-13.

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