HX531 | RXR antagonist | Probechem Biochemicals

Chemical Structure : HX531

CAS No.: 188844-34-0

HX531 (HX 531)

Catalog No.: PC-20776Not For Human Use, Lab Use Only.

HX531 is a potent, pan RXR antagonist with IC50 of 18 nM on retinoidal activity in HL-60 cell assays, HX531 also is a partial PPARγ inhibitor and ameliorates diet-induced obesity and type 2 diabetes.

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25 mg	$348	In stock
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Biological Activity

Physicochemical Properties

M.Wt	483.57
Formula	C29H29N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(O)C1=CC=C(C2=NC3=CC([N+]([O-])=O)=CC=C3N(C)C4=CC5=C(C(C)(C)CCC5(C)C)C=C42)C=C1

References

1. M Ebisawa, et al. Chem Pharm Bull (Tokyo). 1999 Dec;47(12):1778-86.

2. T Yamauchi, et al. J Clin Invest. 2001 Oct;108(7):1001-13.

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HX531 (HX 531)

Biological Activity

Physicochemical Properties

References

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