Chemical Structure : HYOU1 inhibitor 52
CAS No.:
2832155-33-4
HYOU1 inhibitor 52
Catalog No.: PC-21759Not For Human Use, Lab Use Only.
HYOU1 inhibitor 52 is a first-in-class inhibitor for Hypoxia up-regulated protein 1 (HYOU1, GRP170/ORP150), decreases significantly the levels of the cytokine Interleukin 6 (IL-6) in LPS (10 ng/mL)-treated WT-MΦs with IC50 of 0.57 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HYOU1 inhibitor 52 is a first-in-class inhibitor for Hypoxia up-regulated protein 1 (HYOU1, GRP170/ORP150), decreases significantly the levels of the cytokine Interleukin 6 (IL-6) in LPS (10 ng/mL)-treated WT-MΦs with IC50 of 0.57 uM.
HYOU1 inhibitor 52 downregulates the expression of Mmp3 and Bmp2 genes, both being highly upregulated in activated fibroblasts promoting chronic inflammation and fibrosis.
HYOU1 inhibitor 52 inhibits multiple pathways found activated in pathogenic fibroblasts, including extracellular matrisome alteration, TNFsignaling, cytokine/chemokine production and collagen fibril organization.
Physicochemical Properties
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M.Wt
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454.37
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Formula
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C22H26Cl2FN3O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-amino-5-chloro-N-((1-((2-chloro-4-fluorophenyl)amino)cycloheptyl)methyl)-2-methoxybenzamide
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References
1. Papadopoulou D, et al. Angew Chem Int Ed Engl. 2024 Feb 10:e202319157.
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