Chemical Structure : HYPE inhibitor I2.10
CAS No.:
1341007-95-1
HYPE inhibitor I2.10
(AMPylase inhibitor I2.10)
Catalog No.: PC-22137Not For Human Use, Lab Use Only.
HYPE inhibitor I2.10 is a small molecule HYPE (Huntingtin Yeast Interacting Partner E, FICD) enzyme inhibitor with IC50 of 12.1 uM, inhibits HYPE-mediated AMPylation of BiP in vtro.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HYPE inhibitor I2.10 (AMPylase inhibitor I2.10) is a small molecule AMPylase inhibitor, perturbs HYPE-mediated AMPylation of heat shock chaperone binding immunoglobulin protein (BiP) in vitro with IC50 of 12.1 uM.
I2.10 enacts a reliable inhibitory effect of AMPylation on HYPE's primary substrate, the ER chaperone BiP.
I2.10 is especially suited for development as a HYPE-specific drug for the treatment of clinical conditions of neurodegeneration and diabetes.
HYPE resides in the ER (endoplasmic reticulum) where it AMPylates the heat shock chaperone BiP (Binding Immunoglobulin Protein).
Physicochemical Properties
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M.Wt
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279.26
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Formula
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C14H9N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(6-(1H-imidazol-1-yl)pyridin-3-yl)-5-(furan-3-yl)-1,3,4-oxadiazole
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References
1. Ali Camara, et al. Cell Stress Chaperones. 2024 Apr 8:S1355-8145(24)00063-4.
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