Catalog No.: PC-22137Not For Human Use, Lab Use Only.
HYPE inhibitor I2.10 is a small molecule HYPE (Huntingtin Yeast Interacting Partner E, FICD) enzyme inhibitor with IC50 of 12.1 uM, inhibits HYPE-mediated AMPylation of BiP in vtro.
HYPE inhibitor I2.10 is a small molecule HYPE (Huntingtin Yeast Interacting Partner E, FICD) enzyme inhibitor with IC50 of 12.1 uM, inhibits HYPE-mediated AMPylation of BiP in vtro.
I2.10 enacts a reliable inhibitory effect of AMPylation on HYPE's primary substrate, the ER chaperone BiP.
I2.10 is especially suited for development as a HYPE-specific drug for the treatment of clinical conditions of neurodegeneration and diabetes.
HYPE resides in the ER (endoplasmic reticulum) where it AMPylates the heat shock chaperone BiP (Binding Immunoglobulin Protein).
